Royal Air Force Typhoon FGR4s have conducted a mission with French aircraft in a coordinated attack targeting an subterranean weapons facility in Syria employed by the IS group, as stated by the UK Ministry of Defence.
The site, pinpointed through reconnaissance, was believed to be storing arms and explosives, the statement said, and was positioned in hills just above Palmyra in the heart of Syria.
"Our fighter planes utilized laser-guided Paveway IV weapons to target a series of entry passages providing entry to the facility... early reports suggest the objective was successfully hit," the ministry announced.
There was no sign of any harm to civilians in the strike on Saturday evening and each participating jet made a safe return, the defence officials confirmed.
The Typhoon FGR4s were assisted by a Voyager aerial refuelling aircraft.
Daesh - alternatively referred to as the so-called Islamic State - established jihadist rule over large swathes of Syria and Iraq prior to its 2019 collapse.
"This strike underscores British leadership, and resolve to operate in unison with allied nations, to stamp out any revival of the terrorist group and their violent and radical beliefs in the Middle East," Britain's Defence Chief the minister remarked.
UK warplanes have conducted surveillance missions over Syrian airspace to "forestall any attempted resurgence" of Islamic State after its military defeat at the battle of Baghuz in the year 2019, the MoD reported.
"I extend gratitude to the personnel of the UK armed forces participating in this mission for their professionalism and their valour," Healey said. "Including them were numerous British personnel on duty over Christmas and New Year. This operation, to take out dangerous terrorists who threaten our way of life, demonstrates how British military are ready to step up, throughout the year, keeping Britain secure within its borders and strong abroad."
During December, the American forces executed what it termed a "massive strike" targeting IS targets in the country, after an assault killed two US troops and a civilian interpreter in the Palmyra area.
The UN estimates IS still boasts roughly 5-7 thousand fighters in both countries.